Journal: Kidney International Reports

Article Title: Peak Tricuspid Regurgitation Jet Velocity and Kidney Outcomes in Patients With Heart Failure With Preserved Ejection Fraction

doi: 10.1016/j.ekir.2024.07.009

Figure Lengend Snippet: Kaplan-Meier curves for the incidence of ≥30% eGFR decline stratified by quartiles of peak tricuspid regurgitation jet velocity. eGFR, estimated glomerular filtration rate.

Article Snippet: Survival analysis was repeated, considering the following: (i) a Fine and Gray competing risk model with all-cause death as a competing event; (ii) ≥30% eGFR decline observed on at least 2 consecutive visits; (iii) ≥40% eGFR decline; (iv) a discrete-time survival model (approximated by logistic regression using person-time intervals) for ≥30% eGFR decline given that outcome events could only be ascertained at certain visit time points; (v) a Cox regression model for ≥30% eGFR decline, using eGFR values derived only from the protocol-based serum creatinine measures; and (vi) a survival analysis that was restricted to the TOPCAT-Americas (participants from the United States, Canada, Brazil, and Argentina) because there were significant regional differences in the clinical profiles, event rates, and study drug responses in TOPCAT, along with concerns about study conduct at the Russian and Georgian sites.,

Techniques: Filtration

Journal: Kidney International Reports

Article Title: Peak Tricuspid Regurgitation Jet Velocity and Kidney Outcomes in Patients With Heart Failure With Preserved Ejection Fraction

doi: 10.1016/j.ekir.2024.07.009

Figure Lengend Snippet: Association of baseline peak tricuspid regurgitation jet velocity with ≥30% decline in eGFR and doubling of creatinine

Article Snippet: Survival analysis was repeated, considering the following: (i) a Fine and Gray competing risk model with all-cause death as a competing event; (ii) ≥30% eGFR decline observed on at least 2 consecutive visits; (iii) ≥40% eGFR decline; (iv) a discrete-time survival model (approximated by logistic regression using person-time intervals) for ≥30% eGFR decline given that outcome events could only be ascertained at certain visit time points; (v) a Cox regression model for ≥30% eGFR decline, using eGFR values derived only from the protocol-based serum creatinine measures; and (vi) a survival analysis that was restricted to the TOPCAT-Americas (participants from the United States, Canada, Brazil, and Argentina) because there were significant regional differences in the clinical profiles, event rates, and study drug responses in TOPCAT, along with concerns about study conduct at the Russian and Georgian sites.,

Techniques:

Journal: Kidney International Reports

Article Title: Peak Tricuspid Regurgitation Jet Velocity and Kidney Outcomes in Patients With Heart Failure With Preserved Ejection Fraction

doi: 10.1016/j.ekir.2024.07.009

Figure Lengend Snippet: Associations of peak tricuspid regurgitation jet velocity with ≥30% eGFR decline in different subgroups of patients. Effect modification was assessed by baseline age, sex, BMI, LVEF, systolic BP, DM, and randomization group regarding the association between pTRV and ≥30% eGFR decline. P -values for the interaction were computed by adding the interaction term to the multivariable Cox proportional hazards regression model in the primary analysis. BMI, body mass index; BP, blood pressure, DM, diabetes mellitus; LVEF, left ventricular ejection fraction.

Article Snippet: Survival analysis was repeated, considering the following: (i) a Fine and Gray competing risk model with all-cause death as a competing event; (ii) ≥30% eGFR decline observed on at least 2 consecutive visits; (iii) ≥40% eGFR decline; (iv) a discrete-time survival model (approximated by logistic regression using person-time intervals) for ≥30% eGFR decline given that outcome events could only be ascertained at certain visit time points; (v) a Cox regression model for ≥30% eGFR decline, using eGFR values derived only from the protocol-based serum creatinine measures; and (vi) a survival analysis that was restricted to the TOPCAT-Americas (participants from the United States, Canada, Brazil, and Argentina) because there were significant regional differences in the clinical profiles, event rates, and study drug responses in TOPCAT, along with concerns about study conduct at the Russian and Georgian sites.,

Techniques: Modification

Journal: Kidney International Reports

Article Title: Peak Tricuspid Regurgitation Jet Velocity and Kidney Outcomes in Patients With Heart Failure With Preserved Ejection Fraction

doi: 10.1016/j.ekir.2024.07.009

Figure Lengend Snippet: Patient characteristics at baseline stratified by quartiles of peak tricuspid regurgitation jet velocity

Article Snippet: Survival analysis was repeated, considering the following: (i) a Fine and Gray competing risk model with all-cause death as a competing event; (ii) ≥30% eGFR decline observed on at least 2 consecutive visits; (iii) ≥40% eGFR decline; (iv) a discrete-time survival model (approximated by logistic regression using person-time intervals) for ≥30% eGFR decline given that outcome events could only be ascertained at certain visit time points; (v) a Cox regression model for ≥30% eGFR decline, using eGFR values derived only from the protocol-based serum creatinine measures; and (vi) a survival analysis that was restricted to the TOPCAT-Americas (participants from the United States, Canada, Brazil, and Argentina) because there were significant regional differences in the clinical profiles, event rates, and study drug responses in TOPCAT, along with concerns about study conduct at the Russian and Georgian sites.,

Techniques: Medications